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色素沉着部位主要在表皮层以及真皮层。真皮层的代谢非常缓慢，长达十年以上，大家可以看一下自己小时候手上，胳膊上留下的伤疤是不是到现在都没好，那就是因为真皮层受损了。
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可是，晒太阳的人那么多，也不是所有的人都会长色斑啊？那就跟个人的身体素质有关了，身体健康状况不佳，皮肤的代谢不畅，微循环受阻，黑色素无法正常代谢，就会在表皮或者真皮层沉积，形成色斑。某些色斑，例如雀斑，被认为跟遗传基因有关。
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我也就这个问题咨询过浙江皮肤病防治研究所的专家，他告诉我，没有哪种单一的、对皮肤安全无害的化学物质/动植物提取物可以实现彻底祛斑（重金属，激素可以祛斑，但是不用我说，大家都应该知道这些东西对皮肤的危害有多大），所以市面上绝大部分声称可以祛斑的产品要么是吹的要么是添加了重金属/激素，大家不要浪费钱了！